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| Description
| - Ovariectomized (OVX) mice with diet-induced obesity (DIO) serve as a model of postmenopausal women with metabolic syndrome. In our preliminary study, these mice developed a lower sensitivity to central leptin, substantially enhanced weight of adipose tissue and symptoms of metabolic syndrome. Antagonists and inverse agonists of orexigenic hormone ghrelin are promising substances for obesity treatment. Because ghrelin is stimulated both at estrogen deficiency and high fat diet consumption, we propose that inhibition of ghrelin is beneficial especially in OVX mice with DIO. In these mice, we plan to follow effects of ghrelin antagonists and inverse agonists on short-and long-term food intake, body weight, locomotor activity, expression of ghrelin and leptin receptor and neuropeptide Y (NPY) in hypothalamus, metabolism in brown and white adipose tissue, and on symptoms of metabolic syndrome. The results will be compared with those in mice with estrogen supplementation. Ghrelin antagonists and inverse agonists might be useful in treatment of metabolic syndrome in postmenopausal females. (en)
- 1.Testování biologické aktivity ghrelinu a jeho analogů in vitro. 2.Studium vlivu ghrelinu a jeho antagonistů na regulaci příjmu potravy a příznaky metabolického syndromu u obézních ovariektomovaných myších samic s náhradou nebo bez náhrady estrogenu.
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| Title
| - Impact of ghrelin and estrogen on metabolic syndrom of female obese mice (en)
- Vliv ghrelinu a estrogenu na metabolický syndrom u obézních myších samic
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - ghrelin; estrogen; dietou indukovaná obezita; ovariektomie; samice (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Řešení projektu proběhlo výtečně, jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
- The project was excellent, both in terms of expertise and in terms of disbursement of funds. (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - ghrelin
- dietou indukovaná obezita
- estrogen
- ovariektomie
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| is http://linked.open...vavai/cep/projekt
of | |
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