About: Role of tumor specific immune response and circulating tumour cells in the peripheral blood for the clinical course of ovarian cancer.     Goto   Sponge   NotDistinct   Permalink

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  • Ovarian carcinoma is a disease with frequent relapses and high mortality. Bearing this in mind, it is important to search for new therapeutical strategies aimed for eradication of minimal residual disease. It is likely that new knowledge in the field of the immunology of ovarian carcinoma could find new predictive factors, improve monitoring of the disease and help to ameliorate prognosis of the disease. The project is focused on evaluation of infiltration tumour mass by immune system´s cells, to determine expression of chosen tumour antigens and to bring optimal methodics for assesment of circulating tumour cells in peripheral blood. (en)
  • Karcinom ovaria je onemocnění s častým výskytem recidiv a vysokou mortalitou. Pro zlepšení prognózy pacientek je proto potřeba vyvíjet nové terapeutické strategie cílené na eradikaci minimální reziduální nemoci. Prozkoumání nádorové imunologie karcinomu ovaria skýtá nové možnosti v nalezení prediktivních faktorů a v monitoraci léčby a follow-up pacientek . Projekt má vyhodnotit infiltraci nádorové tkáně buňkami imunitního systému, stanovit expresi vybraných nádorových antigenů a přinést optimální metodiku pro stanovení cirkulujících nádorových buněk v periferní krvi.
Title
  • Role of tumor specific immune response and circulating tumour cells in the peripheral blood for the clinical course of ovarian cancer. (en)
  • Význam přítomnosti protinádorové imunity a nádorových buněk v periferní krvi pro klinický průběh karcinomu ovária.
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  • NT14533
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  • immune responce; ovarian cancer, prognosis; follow-up; progession-free interval; circulating tumour cells (en)
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  • ovarian cancer
  • follow-up
  • progession-free interval
  • prognosis
  • immune responce
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