About: Assessment of extent and composition of atherosclerotic plaques in coronary arteries based on ultrasonographic investigation of carotid arteries and polymorphisms of specific genes     Goto   Sponge   NotDistinct   Permalink

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  • I. The proposed project assesses the relationship between ultrasonographic findings in carotid arteries in combination with investigation of genetic polymorphisms of genes involved in gas molecules production. II. Genetic polymorphisms will be studied in endothelial and inducible s nitric oxide synthases (production of NO) and heme oxygenase-1 (production of CO). III. Aim of the study is evaluation of possibilities to predict extent and risk features of atherosclerotic plaques inside coronary arteries based on non-invasive ultrasonic examination of carotid arteries together with analysis of polymorhisms in genes mentioned above. (en)
  • I. Hodnocení vztahu mezi postižením karotických tepen v kombinaci s vyšetřením genetických polymorfismů genů pro proteiny produkující plynné signální molekuly NO a CO a postižením koronárních tepen. II. Genetické polymorfismy budou studovány u endotelové a inducibilní syntázy oxidu dusnatého (produkce NO) a hem oxygenázy-1 (produkce CO). III. Cílem studie je stanovení možnosti predikce koronárního postižení podle neinvazivně vyšetřeného postižení karotid a polymorfizmů ve výše uvedených genech. (cs)
Title
  • Predikce rozsahu a složení aterosklerotických plátů v koronárních tepnách na základě ultrasonografického vyšetření karotických tepen a polymorfizmů vybraných genů (cs)
  • Assessment of extent and composition of atherosclerotic plaques in coronary arteries based on ultrasonographic investigation of carotid arteries and polymorphisms of specific genes (en)
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  • atherosclerosis; intravascular ultrasound; virtual histology; intima media thickness; plaque echogenity; gene polymorphisms; NO and CO; acute coronary syndromes (en)
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