About: Androgen Antagonist APC-100     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Androgen Antagonist APC-100
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Androgen Antagonist APC-100
NCI_META_CUI
  • CL432408
PDQ_Open_Trial_Search_ID
  • 712831
PDQ_Closed_Trial_Search_ID
  • 712831
FULL_SYN
  • Androgen Antagonist APC-100PTNCI
  • APC-100CNNCI
DEFINITION
  • An orally available, vitamin E derivative and androgen receptor (AR) antagonist with potential anti-oxidant, chemopreventative and antineoplastic activity. APC-100 binds to ARs in target tissues thereby inhibiting androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. By inhibiting the formation of the complex between androgen activated AR- and the AP1 transcription factor JunD, the expression of androgen-responsive genes are blocked. One of such gene is spermidine/spermine N1-acetyl transferase gene (SSAT) that is responsible for the breakdown of polyamines, which are produced in high levels by prostatic epithelial cells, into reactive oxygen species (ROS) that cause cellular damage. APC-100 may ultimately lead to an inhibition of growth in both AR-dependent and AR-independent prostate tumor cells.NCI
code
  • C98290
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