About: CDK4/6 Dual Inhibitor LY2835219     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CDK4/6 Dual Inhibitor LY2835219
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CDK4/6 Dual Inhibitor LY2835219
NCI_META_CUI
  • CL430316
PDQ_Open_Trial_Search_ID
  • 706364
PDQ_Closed_Trial_Search_ID
  • 706364
FULL_SYN
  • CDK4/6 Dual Inhibitor LY2835219PTNCI
  • LY2835219CNNCI
DEFINITION
  • An orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.NCI
code
  • C97660
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