About: VEGFR/PDGFR Dual Kinase Inhibitor X-82     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • VEGFR/PDGFR Dual Kinase Inhibitor X-82
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • VEGFR/PDGFR Dual Kinase Inhibitor X-82
NCI_META_CUI
  • CL428293
PDQ_Open_Trial_Search_ID
  • 695817
PDQ_Closed_Trial_Search_ID
  • 695817
FULL_SYN
  • X-82CNNCI
  • VEGFR/PDGFR Dual Kinase Inhibitor X-82PTNCI
DEFINITION
  • An orally available small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities. VEGFR/PDGFR dual kinase inhibitor X-82 inhibits all isoforms of VEGFR and PDGFR, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and PDGFRs are receptor tyrosine kinases that may be upregulated in various tumor cell types. VEGFR/PDGFR dual kinase inhibitor X-82 has been shown to reduce tissue toxicity by 95 percent compared with first-generation kinase inhibitors.NCI
code
  • C95896
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