About: JAK2 Inhibitor BMS-911543     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • JAK2 Inhibitor BMS-911543
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • JAK2 Inhibitor BMS-911543
NCI_META_CUI
  • CL428168
PDQ_Open_Trial_Search_ID
  • 689517
PDQ_Closed_Trial_Search_ID
  • 689517
FULL_SYN
  • JAK2 Inhibitor BMS-911543PTNCI
  • BMS-911543CNNCI
DEFINITION
  • An orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS-911543 selectively inhibits JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.NCI
code
  • C95702
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