About: pan-CDK Inhibitor BAY1000394     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • pan-CDK Inhibitor BAY1000394
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • pan-CDK Inhibitor BAY1000394
NCI_META_CUI
  • CL423828
PDQ_Open_Trial_Search_ID
  • 684718
PDQ_Closed_Trial_Search_ID
  • 684718
FULL_SYN
  • pan-CDK Inhibitor BAY1000394PTNCI
  • BAY1000394CNNCI
DEFINITION
  • An orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. pan-CDK inhibitor BAY1000394 selectively binds to and inhibits the activity of CDK1/Cyclin B, CDK2/Cyclin E, CDK4/Cyclin D1, and CDK9/Cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle progression and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are often dysregulated in cancerous cells.NCI
code
  • C92579
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