About: Androgen Receptor Antagonist ARN-509     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Androgen Receptor Antagonist ARN-509
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Androgen Receptor Antagonist ARN-509
NCI_META_CUI
  • CL421676
PDQ_Open_Trial_Search_ID
  • 683082
PDQ_Closed_Trial_Search_ID
  • 683082
FULL_SYN
  • Androgen Receptor Antagonist ARN-509PTNCI
  • ARN-509CNNCI
DEFINITION
  • A small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.NCI
code
  • C92574
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