About: JAK2 Inhibitor XL019     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • JAK2 Inhibitor XL019
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • JAK2 Inhibitor XL019
NCI_META_CUI
  • CL416257
PDQ_Open_Trial_Search_ID
  • 667451
PDQ_Closed_Trial_Search_ID
  • 667451
FULL_SYN
  • XL019CNNCI
  • JAK2 Inhibitor XL019PTNCI
DEFINITION
  • An orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. XL019 inhibits the activation of JAK2 as well as the mutated form JAK2V617F, which may result in the inhibition of the JAK-STAT signaling pathway and may induce apoptosis. The JAK2 mutated form JAK2V617F has a valine-to-phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival.NCI
code
  • C90573
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