About: MET Tyrosine Kinase Inhibitor EMD 1214063     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • MET Tyrosine Kinase Inhibitor EMD 1214063
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • MET Tyrosine Kinase Inhibitor EMD 1214063
NCI_META_CUI
  • CL413569
PDQ_Open_Trial_Search_ID
  • 660212
PDQ_Closed_Trial_Search_ID
  • 660212
FULL_SYN
  • MET Tyrosine Kinase Inhibitor EMD 1214063PTNCI
  • EMD 1214063CNNCI
DEFINITION
  • An inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor EMD 1214063 selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase. The receptor tyrosine kinase MET (also known as hepatocyte growth factor receptor or HGFR), is the product of the proto-oncogene c-Met and is overexpressed or mutated in many tumor cell types; this protein plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.NCI
code
  • C88314
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