About: CDK2/TRKA Inhibitor PHA-848125 AC     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CDK2/TRKA Inhibitor PHA-848125 AC
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CDK2/TRKA Inhibitor PHA-848125 AC
NCI_META_CUI
  • CL413567
PDQ_Open_Trial_Search_ID
  • 660138
PDQ_Closed_Trial_Search_ID
  • 660138
FULL_SYN
  • PHA-848125 ACCNNCI
  • N,1,4,4-Tetramethyl-8-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamideSNNCI
  • CDK2/TRKA Inhibitor PHA-848125 ACPTNCI
DEFINITION
  • An orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA), with potential antineoplastic activity. CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. CDKs are serine/threonine kinases involved in regulation of the cell cycle and may be overexpressed in some cancer cell types. The neurotrophin receptor TRKA is mutated in a variety of cancer cell types.NCI
code
  • C88312
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