About: Carvedilol Phosphate Extended-Release Capsule     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Carvedilol Phosphate Extended-Release Capsule
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Carvedilol Phosphate Extended-Release Capsule
NCI_META_CUI
  • CL413548
PDQ_Open_Trial_Search_ID
  • 658712
PDQ_Closed_Trial_Search_ID
  • 658712
FULL_SYN
  • Carvedilol Phosphate Extended-Release CapsulePTNCI
  • Coreg CRBRNCI
DEFINITION
  • An extended-release capsule formulation containing the phosphate salt of carvedilol, a nonselective beta-adrenergic blocking agent with alpha 1-adrenergic blocking activity. Carvedilol is a racemic mixture; the S(-) enantiomer non-selectively binds to and blocks beta-adrenergic receptors, exerting negative inotropic and chronotropic effects, leading to a reduction in cardiac output. Both R(+) and S(-) enantiomers bind to and block alpha 1-adrenergic receptors with equal potency, causing vasodilation and a reduction in peripheral vascular resistance. This agent has no intrinsic sympathomimetic activity.NCI
code
  • C88298
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