About: JAK2 Inhibitor TG101348     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • JAK2 Inhibitor TG101348
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • JAK2 Inhibitor TG101348
UMLS_CUI
  • C2353170
PDQ_Open_Trial_Search_ID
  • 657793
PDQ_Closed_Trial_Search_ID
  • 657793
FULL_SYN
  • JAK2 Inhibitor TG101348PTNCI
  • TG101348CNNCI
  • SAR302503CNNCI
DEFINITION
  • An orally bioavailable, small-molecule, ATP-competitive inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor TG101348 competes with JAK2 as well as the mutated form AK2V617F for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and the induction of tumor cell apoptosis. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders (MPDs); the mutated form JAK2V617F has a valine-to-phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival.NCI
code
  • C88293
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