About: VEGFR Inhibitor KRN951     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • VEGFR Inhibitor KRN951
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • VEGFR Inhibitor KRN951
NCI_META_CUI
  • CL412453
PDQ_Open_Trial_Search_ID
  • 655018
PDQ_Closed_Trial_Search_ID
  • 655018
FULL_SYN
  • N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N'-(5-methyl-3-isoxazolyl) Urea Hydrochloride MonohydrateSYNCI
  • KRN951CNNCI
  • VEGFR Inhibitor KRN951PTNCI
DEFINITION
  • An orally bioavailable quinoline-urea derivative inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1 and 2 with potential antiangiogenesis and antineoplastic activities. VEGFR inhibitor KRN951 inhibits VEGF-induced phosphorylation of VEGFRs 1 and 2, which may result in inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor cell types.NCI
code
  • C88267
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