About: Zabicipril     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Zabicipril
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Zabicipril
UMLS_CUI
  • C0085048
CAS_Registry
  • 83059-56-7
FDA_UNII_Code
  • 475035SS4C
Contributing_Source
  • FDA
Chemical_Formula
  • C23H32N2O5
Legacy_Concept_Name
  • Zabicipril
FULL_SYN
  • (3S)-2-((2S)-N-((1S)-1-Carboxy-3-phenylpropyl)alanyl)-2-azabicyclo(2.2.2)octane-3-carboxylic Acid, 1-ethyl EsterSNNCI
  • ZABICIPRILPTFDA475035SS4C
  • ZabiciprilPTNCI
DEFINITION
  • A non-thiol angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zabicipril is rapidly converted in vivo by de-esterification into its active form zabiciprilat. Zabiciprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zabiciprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.NCI
code
  • C82218
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