About: MET Tyrosine Kinase Inhibitor PF-04217903     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • MET Tyrosine Kinase Inhibitor PF-04217903
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • MET Tyrosine Kinase Inhibitor PF-04217903
UMLS_CUI
  • C2703125
PDQ_Open_Trial_Search_ID
  • 601032
PDQ_Closed_Trial_Search_ID
  • 601032
Legacy_Concept_Name
  • MET_Tyrosine_Kinase_Inhibitor_PF-04217903
FULL_SYN
  • MET Tyrosine Kinase Inhibitor PF-04217903PTNCI
  • PF-04217903CNNCI
DEFINITION
  • An orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met. The receptor tyrosine kinase c-Met, also known as hepatocyte growth factor (HGF) receptor, is overexpressed or mutated in many tumor cell types, playing an important role in tumor cell proliferation, survival, invasion, and metastasis and angiogenesis.NCI
code
  • C78483
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