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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Benazeprilat
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Benazeprilat
UMLS_CUI
  • C0105523
CAS_Registry
  • 86541-78-8
FDA_UNII_Code
  • JRM708L703
Contributing_Source
  • FDA
Chemical_Formula
  • C22H24N2O5
Legacy_Concept_Name
  • Benazeprilat
FULL_SYN
  • BENAZEPRILATPTFDAJRM708L703
  • BenazeprilatPTNCI
DEFINITION
  • The active metabolite of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Once the prodrug benazepril is metabolized to benazeprilat in the liver, benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.NCI
code
  • C72907
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