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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Linifanib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Linifanib
UMLS_CUI
  • C1737951
CAS_Registry
  • 796967-16-3
FDA_UNII_Code
  • CO93X137CW
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of several types of cancer. ABT-869 blocks the action of several growth factors. It may also block the growth of new blood vessels that tumors need to grow and may cause cancer cells to die. It is a type of receptor tyrosine kinase inhibitor and a type of angiogensis inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 558913
PDQ_Closed_Trial_Search_ID
  • 558913
Chemical_Formula
  • C21H18FN5O
Legacy_Concept_Name
  • Receptor_Tyrosine_Kinase_Inhibitor_ABT-869
FULL_SYN
  • multitargeted receptor tyrosine kinase inhibitor ABT-869PTNCI-GLOSSCDR0000641978
  • ABT-869PTNCI-GLOSSCDR0000641976
  • LINIFANIBPTFDACO93X137CW
  • ABT-869CNNCI
  • LinifanibPTNCI
DEFINITION
  • An orally bioavailable receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as FMS-related tyrosine kinase receptor-3 (FLT3).NCI
code
  • C71759
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