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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Givinostat
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Givinostat
UMLS_CUI
  • C1571394
CAS_Registry
  • 497833-27-9
FDA_UNII_Code
  • 5P60F84FBH
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 560751
PDQ_Closed_Trial_Search_ID
  • 560751
Chemical_Formula
  • C24H27N3O4
Legacy_Concept_Name
  • HDAC_Inhibitor_ITF2357
FULL_SYN
  • ITF2357CNNCI
  • GIVINOSTATPTFDA5P60F84FBH
  • GavinostatSYNCI
  • GivinostatPTNCI
DEFINITION
  • An orally bioavailable hydroxymate inhibitor of histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Givinostat inhibits class I and class II HDACs, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. At low, nonapoptotic concentrations, this agent inhibits the production of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-6 and interferon-gamma. Givinostat has also been shown to activate the intrinsic apoptotic pathway, inducing apoptosis in hepatoma cells and leukemic cells. This agent may also exhibit anti-angiogenic activity, inhibiting the production of angiogenic factors such as IL-6 and vascular endothelial cell growth factor (VEGF) by bone marrow stromal cells.NCI
code
  • C71716
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