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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Spirapril
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Spirapril
UMLS_CUI
  • C0075007
CAS_Registry
  • 83647-97-6
FDA_UNII_Code
  • 96U2K78I3V
Contributing_Source
  • FDA
Chemical_Formula
  • C22H30N2O5S2
Legacy_Concept_Name
  • Spirapril
FULL_SYN
  • SPIRAPRILPTFDA96U2K78I3V
  • SpiraprilPTNCI
DEFINITION
  • A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its active metabolite spiraprilat. Spiraprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Spiraprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.NCI
code
  • C66560
is Has_Free_Acid_Or_Base_Form of
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