About: Amodiaquine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amodiaquine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amodiaquine Hydrochloride
UMLS_CUI
  • C0982016
CAS_Registry
  • 6398-98-7
FDA_UNII_Code
  • K6PW2S574L
Contributing_Source
  • FDA
Chemical_Formula
  • C20H22ClN3O.2ClH.2H2O
Legacy_Concept_Name
  • Amodiaquine_Hydrochloride
CHEBI_ID
  • CHEBI:50652
FULL_SYN
  • Amodiaquine HydrochloridePTNCI
  • AMODIAQUINE HYDROCHLORIDEPTFDAK6PW2S574L
DEFINITION
  • The hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites.NCI
code
  • C65232
is Has_Salt_Form of
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