About: PM00104     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • PM00104
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PM00104
PubMedID_Primary_Reference
  • 19584237
UMLS_CUI
  • C1568937
PDQ_Open_Trial_Search_ID
  • 502184
PDQ_Closed_Trial_Search_ID
  • 502184
Legacy_Concept_Name
  • PM00104
FULL_SYN
  • PM00104PTNCI
  • ZalypsisBRNCI
DEFINITION
  • A synthetic alkaloid compound, related to natural alkaloid compounds, found in molluscs (jorumycin) and sponges (renieramycins), with potential antineoplastic activity. PM00104 reversibly binds to DNA, thereby inducing cytotoxicity due to its interference with DNA replication, transcription, and translation processes. DNA binding by this agent does not trigger DNA damage checkpoint responses, hence PM00104 demonstrates a manageable and reversible cytotoxicity as part of its antitumor activity.NCI
code
  • C62763
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