About: CDK Inhibitor SNS-032     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CDK Inhibitor SNS-032
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CDK Inhibitor SNS-032
UMLS_CUI
  • C1451099
PDQ_Open_Trial_Search_ID
  • 488948
PDQ_Closed_Trial_Search_ID
  • 488948
Legacy_Concept_Name
  • SNS-032
FULL_SYN
  • SNS-032CNNCI
  • CDK Inhibitor SNS-032PTNCI
  • BMS-387032CNNCI
DEFINITION
  • A small aminothiazole molecule and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. SNS-032 binds to and prevents the phosphorylation of cyclin-dependent kinases, especially CDK2, 7, and 9 that regulate cell cycle progression. Inhibition of CDKs leads to cell cycle arrest and induces apoptosis. As a result, this agent causes cytotoxicity and prevents further tumor cell growth.NCI
code
  • C62523
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