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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Terbutaline
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Terbutaline
UMLS_CUI
  • C0039542
CAS_Registry
  • 23031-25-6
FDA_UNII_Code
  • N8ONU3L3PG
Contributing_Source
  • FDA
Chemical_Formula
  • C12H19NO3
Legacy_Concept_Name
  • Terbutaline
CHEBI_ID
  • CHEBI:9449
FULL_SYN
  • TerbutalinePTNCI
  • TERBUTALINEPTFDAN8ONU3L3PG
DEFINITION
  • An ethanolamine derivative with bronchodilating and tocolytic activities. Terbutaline selectively binds to and activates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric G protein and subsequent increase in cyclic AMP (cAMP) production. Increased cAMP levels result in relaxation of bronchial and vascular smooth muscle mediated through the activation of protein kinase A (PKA), which phosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration of intracellular calcium all of which aids in the relaxation of airway muscles. Terbutaline also increases mucociliary clearance and reduces release of inflammatory cell mediators.NCI
code
  • C61965
is Has_Free_Acid_Or_Base_Form of
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