About: Polymyxin B     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Polymyxin B
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Polymyxin B
UMLS_CUI
  • C0032535
CAS_Registry
  • 1404-26-8
FDA_UNII_Code
  • J2VZ07J96K
Contributing_Source
  • FDA
Legacy_Concept_Name
  • Polymyxin_B
FULL_SYN
  • Polymyxin BPTNCI
  • POLYMYXIN BPTFDAJ2VZ07J96K
DEFINITION
  • A mixture of the polypeptides polymyxins B1 and B2, both obtained from Bacillus polymyxa strains, with antimicrobial activity. Polymyxin B exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.NCI
code
  • C61894
is Has_Free_Acid_Or_Base_Form of
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