About: Pegylated Liposomal Belotecan     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pegylated Liposomal Belotecan
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pegylated Liposomal Belotecan
UMLS_CUI
  • C1831764
PDQ_Open_Trial_Search_ID
  • 471934
PDQ_Closed_Trial_Search_ID
  • 471934
Legacy_Concept_Name
  • S-CKD602
FULL_SYN
  • STEALTH Liposomal BelotecanSYNCI
  • Pegylated Liposomal BelotecanPTNCI
  • S-CKD602CNNCI
DEFINITION
  • A sterically stabilized, pegylated liposomal formulation containing belotecan, a semi-synthetic analogue of campthotecin with potential antitumor activity. Belotecan inhibits the action of topoisomerase I, an enzyme that produces reversible single-strand breaks in DNA during DNA replication. This agent stabilizes the topoisomerase I and DNA complex, resulting in the inhibition of religation of DNA breaks, inhibition of DNA replication, and apoptotic cell death. The polyethylene glycol coating allows for greater plasma circulation time, thus enhancing the concentration of belotecan at the tumor site. Encapsulation of belotecan preserves the active lactone form, resulting in an increased cytotoxic effect of belotecan.NCI
code
  • C61437
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