About: Pazopanib Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pazopanib Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pazopanib Hydrochloride
NSC_Code
  • 737754
UMLS_CUI
  • C1872226
CAS_Registry
  • 635702-64-6
FDA_UNII_Code
  • 33Y9ANM545
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat kidney cancer and is being studied in the treatment of other types of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of protein tyrosine kinase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 476479
PDQ_Closed_Trial_Search_ID
  • 476479
Chemical_Formula
  • C21H23N7O2S.HCl
Legacy_Concept_Name
  • Pazopanib
FULL_SYN
  • pazopanib hydrochloridePTNCI-GLOSSCDR0000527219
  • Pazopanib HydrochloridePTNCI
  • PAZOPANIB HYDROCHLORIDEPTFDA33Y9ANM545
  • 5-((4-((2,3-Dimethyl-2h-Indazol-6-Yl)Methylamino)Pyrimidin-2-yl)Amino)-2-Methylbenzenesulfonamide MonohydrochlorideSNNCI
  • VotrientPTNCI-GLOSSCDR0000658368
  • VotrientBRNCI
  • GW786034BCNNCI
DEFINITION
  • The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.NCI
code
  • C60779
is Has_Salt_Form of
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