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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • ATN-161
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • ATN-161
UMLS_CUI
  • C1706674
ALT_DEFINITION
  • A substance being studied in the treatment of some types of cancer. ATN-161 may prevent the spread of tumor cells and may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 459774
PDQ_Closed_Trial_Search_ID
  • 459774
Legacy_Concept_Name
  • ATN-161
FULL_SYN
  • ATN-161PTNCI-GLOSSCDR0000518301
  • ATN-161PTNCI
DEFINITION
  • A small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN-161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby preventing integrin alpha5beta1 binding. This receptor blockade may result in inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, angiogenesis, and tumor progression. Integrin alpha5beta1 is expressed on endothelial cells and plays a crucial role in endothelial cell adhesion and migration.NCI
code
  • C52185
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