About: Thiothixene Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Thiothixene Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Thiothixene Hydrochloride
UMLS_CUI
  • C0304386
CAS_Registry
  • 49746-09-0
FDA_UNII_Code
  • B3CRJ1EWJU
Contributing_Source
  • FDA
Chemical_Formula
  • C23H29N3O2S2.2HCl.2H2O
Legacy_Concept_Name
  • Thiothixene_Hydrochloride
FULL_SYN
  • Thiothixene HydrochloridePTNCI
  • NavaneBRNCI
  • THIOTHIXENE HYDROCHLORIDEPTFDAB3CRJ1EWJU
  • 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, Dihydrochloride, DihydrateSNNCI
  • CP 12252-1CNNCI
DEFINITION
  • The hydrochloride salt form of thiothixene, a thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors.NCI
code
  • C47753
is Has_Salt_Form of
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