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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Thiothixene
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Thiothixene
NSC_Code
  • 108165
UMLS_CUI
  • C0039955
CAS_Registry
  • 3313-26-6
FDA_UNII_Code
  • 7318FJ13YJ
Contributing_Source
  • FDA
Chemical_Formula
  • C23H29N3O2S2
Legacy_Concept_Name
  • Thiothixene
FULL_SYN
  • ThiothixenePTNCI
  • Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-SNNCI
  • NavaronSYNCI
  • P-4657 BCNNCI
  • N,N-Dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9H-thioxanthene-2-sulphonamideSNNCI
  • THIOTHIXENEPTFDA7318FJ13YJ
  • OrbinamonSYNCI
  • 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-SNNCI
DEFINITION
  • A thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors.NCI
code
  • C47752
is Has_Free_Acid_Or_Base_Form of
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