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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sulfadoxine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sulfadoxine
UMLS_CUI
  • C0038679
CAS_Registry
  • 2447-57-6
FDA_UNII_Code
  • 88463U4SM5
Contributing_Source
  • FDA
Chemical_Formula
  • C12H14N4O4S
Legacy_Concept_Name
  • Sulfadoxine
CHEBI_ID
  • CHEBI:9329
FULL_SYN
  • N'-(5,6-Dimethoxy-4-pyrimidyl)sulfanilamideSNNCI
  • SulfadoxinePTNCI
  • SULFADOXINEPTFDA88463U4SM5
  • Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-SNNCI
DEFINITION
  • A broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties. Sulfadoxine competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of parasitic folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.NCI
code
  • C47735
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