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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Primidone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Primidone
NSC_Code
  • 41701
UMLS_CUI
  • C0033148
CAS_Registry
  • 125-33-7
FDA_UNII_Code
  • 13AFD7670Q
Contributing_Source
  • FDA
Chemical_Formula
  • C12H14N2O2
Legacy_Concept_Name
  • Primidone
CHEBI_ID
  • CHEBI:8412
FULL_SYN
  • Mysoline, Apo-PrimidoneFBNCI
  • PRIMIDONEPTFDA13AFD7670Q
  • MyidoneBRNCI
  • MysedonSYNCI
  • NeurosynSYNCI
  • 2-DeoxyphenobarbitalSYNCI
  • PrimidonePTNCI
  • 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-SNNCI
  • PrimacloneSYNCI
DEFINITION
  • An analog of phenobarbital with antiepileptic property. Although the mechanism of action has not been fully elucidated, primidone probably exerts its actions, in a manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A receptor/chloride ionophore complex, which leads to prolonged and increased frequency of opening of the chloride channel within the receptor complex. This results in an alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization and prevention of partial and tonic-clonic seizures. In addition, this agent is partially metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute to its anti-seizure properties.NCI
code
  • C47686
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