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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Mefloquine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Mefloquine Hydrochloride
NSC_Code
  • 157387
UMLS_CUI
  • C0699989
CAS_Registry
  • 51773-92-3
FDA_UNII_Code
  • 5Y9L3636O3
Contributing_Source
  • FDA
Chemical_Formula
  • C17H16F6N2O.HCl
Legacy_Concept_Name
  • Mefloquine_Hydrochloride
FULL_SYN
  • Ro 21-5998/001CNNCI
  • Mefloquine HydrochloridePTNCI
  • MEFLOQUINE HYDROCHLORIDEPTFDA5Y9L3636O3
  • LariamBRNCI
  • DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol MonohydrochlorideSNNCI
  • MephaquinSYNCI
DEFINITION
  • The hydrochloride salt form of mefloquine, a piperidinyl quinidine with antimalarial activity. Although the exact mechanism of mefloquine hydrochloride is largely unknown, this agent acts as a blood schizonticide and probably exert its actions by interacting with the phospholipid bilayer, thereby interfering with the stability of the cell membrane and causing cell lysis. Mefloquine hydrochloride is active against Plasmodium falciparum and Plasmodium vivax.NCI
code
  • C47600
is Has_Salt_Form of
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