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AttributesValues
rdf:type
rdfs:label
  • Azelaic Acid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Azelaic Acid
NSC_Code
  • 19493
UMLS_CUI
  • C0052761
CAS_Registry
  • 123-99-9
FDA_UNII_Code
  • F2VW3D43YT
Contributing_Source
  • FDA
Chemical_Formula
  • C9H16O4
Legacy_Concept_Name
  • Azelaic_Acid
CHEBI_ID
  • CHEBI:48131
FULL_SYN
  • Azelaic AcidPTNCI
  • Heptanedicarboxylic AcidSYNCI
  • Lepargylic AcidSYNCI
  • AzelexBRNCI
  • FinaceaBRNCI
  • ZK 62498CNNCI
  • 1,9-Nonanedioic AcidSNNCI
  • AZELAIC ACIDPTFDAF2VW3D43YT
DEFINITION
  • A naturally occurring dicarboxylic acid produced by Malassezia furfur and found in whole grain cereals, rye, barley and animal products. Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins. Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers. Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygen radical. This drug is used topically to reduce inflammation associated with acne and rosacea.NCI
code
  • C47407
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