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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CD3 Complex
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • CD3 Complex
UMLS_CUI
  • C0108779
Legacy_Concept_Name
  • CD3_Complex
FULL_SYN
  • CD3 ComplexPTNCI
  • CD3 ComplexSYNCITCGA
  • CD3SYNCI
  • T-Cell Surface Glycoprotein CD3SYNCI
DEFINITION
  • Consisting of cell surface type I membrane Delta, Epsilon, Gamma, Zeta, and Eta protein subunits with ITAM domains and noncovalently associated with the disulfide bound heterodimeric alpha/beta and gamma/delta TCR, the CD3 complex couples receptor antigen recognition to signal transduction pathways during T-cell activation. During TCR engagement with MHC-associated antigen on host cell surfaces and synapse formation, CD3 activity leads to Tyr-phosphorylated CD3 subunits, Tyr phosphorylation of LAT colocalized in lipid rafts, and MAPK activation. CD3 signal transduction appears to involve LCK, ZAP70, Nck, SLA, SLA2, and DOCK2. CD3 subunits may also associate with the cytoskeleton. CD3 also mediates TCR signal transduction during the developmental transition through positive selection of immature thymocytes to mature CD4+ or CD8+ T cells. (NCI)NCI
code
  • C38897
is someValuesFrom of
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