About: Interferon Alpha Receptor Complex

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About: Interferon Alpha Receptor Complex Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Interferon Alpha Receptor Complex
rdfs:subClassOf	Protein or Riboprotein Complex nodeID://b683328 nodeID://b683329 nodeID://b683330 nodeID://b683331
Semantic_Type	Receptor
Preferred_Name	Interferon Alpha Receptor Complex
UMLS_CUI	C0254653
Legacy_Concept_Name	Interferon_Alpha_Receptor_Complex
FULL_SYN	Interferon Alpha Receptor ComplexPTNCI Interferon Beta ReceptorSYNCI Interferon Alpha ReceptorSYNCI Interferon-Alpha-Beta ReceptorSYNCI
DEFINITION	Human Interferon Alpha Receptor Complex (Type II Cytokine Family Receptor) is a ubiquitous type I membrane protein heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI)NCI
code	C37274
is someValuesFrom of	nodeID://b683306 nodeID://b683314 nodeID://b683323 nodeID://b708211 nodeID://b719331
is Has_Target of	INTERFERON ALFA-2B

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