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AttributesValues
rdf:type
rdfs:label
  • Perphenazine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Perphenazine
NSC_Code
  • 150866
UMLS_CUI
  • C0031184
CAS_Registry
  • 58-39-9
FDA_UNII_Code
  • FTA7XXY4EZ
Contributing_Source
  • FDA
Chemical_Formula
  • C21H26ClN3OS
Legacy_Concept_Name
  • Perphenazine
CHEBI_ID
  • CHEBI:8028
FULL_SYN
  • PERPHENAZINEPTFDAFTA7XXY4EZ
  • 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanolPTDCP06627
  • PerphenazinePTNCI
  • 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanolSNNCI
DEFINITION
  • A phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as hallucinations and delusions. Perphenazine appears to exert its antiemetic activity by blocking the dopamine and histamine-1 receptor in the CTZ thereby relieving nausea and vomiting in the brain. In addition, perphenazine binds to alpha-adrenergic receptors.NCI
code
  • C29355
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