About: Mouse Precursor B Cell Lymphoblastic Lymphoma and Leukemia     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Mouse Precursor B Cell Lymphoblastic Lymphoma and Leukemia
rdfs:subClassOf
Semantic_Type
  • Neoplastic Process
Display_Name
  • Precursor B Cell Lymphoblastic Lymphoma/Leukemia
Preferred_Name
  • Mouse Precursor B Cell Lymphoblastic Lymphoma and Leukemia
UMLS_CUI
  • C1524007
ALT_DEFINITION
  • Precursor B-cell lymphoblastic lymphoma and leukemia. The use of the same name in the 2 species seems appropriate because of highly similar histologic, cytologic, phenotypic, and molecular features; Occurrence: Uncommon spontaneous neoplasm of inbred mice.MMHCC
  • Phenotype: Immature B cell, sIg-. B220+ CD19+ CD43+ CD43- Ly6d (ThB)+ Tdt+; Molecular: Clonal precursor B cell, IgH G/R, IgK G/G; Characteristic: High grade; Presumed cell of origin: Bone marrow precursor B-cell lymphoblast; Differential diagnosis: Histologically and cytologically indistinguishable from most pre-T lymphoblastic lymphoma, Burkitt lymphoma, and Burkitt-like lymphoma, but CD3- sIg- TdT+; Human counterpart and commentary.MMHCC
  • Frequent in some GEM and mice infected with acutely transforming MuLV; Necropsy findings: Splenomegaly, generalized lymphadenopathy, usually with extensive spread to liver, kidney, and lungs, sometimes to meninges with skull exostoses and hind limb paralysis; leukemic form in about one third of cases; Cell size: Medium, uniform; Cytoplasm: Scant; Nuclei: Round or ovoid; chromatin fine; Nucleoli: Variable, often single, central and prominent but sometimes small and multiple; Mitoses: Numerous; Pattern: Diffuse, sometimes starry sky because of apoptosis.MMHCC
Legacy_Concept_Name
  • Mouse_Precursor_B_Cell_Lymphoblastic_Lymphoma_Leukemia
FULL_SYN
  • Lymphoblastic leukemiaSYCTRM
  • Lymphoblastic lymphomaSYCTRM
  • Mouse Precursor B Cell Lymphoblastic Lymphoma and LeukemiaPTNCI
  • Precursor B Cell Lymphoblastic Lymphoma/LeukemiaDNCTRM
  • pre-B LBLSYCTRM
Subsource
  • Herbert Morse III, M.D.; Jerrold Ward, D.V.M., Ph.D.
code
  • C21907
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