About: Mycophenolate Mofetil

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Mycophenolate Mofetil Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Mycophenolate Mofetil
rdfs:subClassOf	Inosine Monophosphate Dehydrogenase Inhibitor IMMUNE SUPPRESSANTS
Has_Salt_Form	MYCOPHENOLATE MOFETIL HYDROCHLORIDE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Mycophenolate Mofetil
NSC_Code	724229
UMLS_CUI	C0209368
CAS_Registry	115007-34-6 128794-94-5
Accepted_Therapeutic_Use_For	Heart transplantation; Kidney transplantation; Liver transplantation; Lupus nephritis
FDA_UNII_Code	9242ECW6R0
Contributing_Source	FDA
ALT_DEFINITION	A drug used to prevent graft-versus-host disease (GVHD) after organ transplants. It is also being studied in the prevention of GVHD after stem cell transplants for cancer, and in the treatment of some autoimmune disorders. Mycophenolate mofetil is a type of immunosuppressive agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42797
PDQ_Closed_Trial_Search_ID	42797
Chemical_Formula	C23H31NO7
Legacy_Concept_Name	Mycophenolate_Mofetil
FULL_SYN	MMFABNCI MYCOPHENOLATE MOFETILPTFDA9242ECW6R0 mycophenolate mofetilPTNCI-GLOSSCDR0000045554 CellCeptPTNCI-GLOSSCDR0000413943 CellceptBRNCI Mycophenolate MofetilPTNCI
DEFINITION	The morpholinoethyl ester of mycophenolic acid (MPA) with potent immunosuppressive properties. Mycophenolate stops T-cell and B-cell proliferation through selective inhibition of the de novo pathway of purine biosynthesis. In vivo, the active metabolite, MPA, reversibly inhibits inosine 5'-monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of guanine nucleotides. MPA displays high lymphocyte specificity and cytotoxicity due to the higher dependence of activated lymphocytes on both salvage and de novo synthesis of guanine nucleotides relative to other cell types. (NCI04)NCI
code	C1468
is someValuesFrom of	nodeID://b646314 nodeID://b663754 nodeID://b663759 nodeID://b673592 nodeID://b692920 nodeID://b693001 nodeID://b694234
is Has_Free_Acid_Or_Base_Form of	MYCOPHENOLATE MOFETIL HYDROCHLORIDE

Faceted Search & Find service v1.16.121 as of Mar 31 2025

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 14 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software