About: Triciribine Phosphate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Triciribine Phosphate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Triciribine Phosphate
NSC_Code
  • 280594
UMLS_CUI
  • C0077070
CAS_Registry
  • 61966-08-3
FDA_UNII_Code
  • 5L5GE3DV88
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39723
PDQ_Closed_Trial_Search_ID
  • 39723
Chemical_Formula
  • C13H17N6O7P
Legacy_Concept_Name
  • Triciribine_Phosphate
FULL_SYN
  • TriciribineSYDTPNSC0154020
  • 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-1,4,5, 6,8-pentaazaacenaphthylen-3-amineSNNCI
  • Tricycloside PhosphateSYNCI
  • 1,4, 5,6,8-pentaazaacenaphthylen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)- (9CI)SNNCI
  • TriciribineSYNCI
  • Tricyclic Nucleoside 5'-PhosphateSNNCI
  • TRICIRIBINE PHOSPHATEPTFDA5L5GE3DV88
  • 1,4,5,6, 8-pentaazaacenaphthalen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)SNNCI
  • TriciribinePTDCP50714
  • TCNABNCI
  • 1, 5-Dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-1,4,5, 6,8-pentaazaacenaphthylen-3-amineSYDTPNSC0280594
  • 3-amino-1, 5-dihydro-5-methyl-1-.beta.-D-ribofuranosyl-1,4,5,6, 8-pentaazaacenaphthylene 5'-(dihydrogen phosphate)SNNCI
  • 3-Amino-1, 5-dihydro-5-methyl-1-.beta.-D-ribofuranosyl-1,4,5,6, 8-pentaazaacenaphthylene 5'-(dihydrogen phosphate)SYDTPNSC0280594
  • 1,4,5,6, 8-Pentaazaacenaphthalen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-SYDTPNSC0280594
  • 1,4, 5,6,8-Pentaazaacenaphthylen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)- (9CI)SYDTPNSC0280594
  • Triciribine PhosphatePTNCI
DEFINITION
  • The phosphate salt of the synthetic, cell-permeable tricyclic nucleoside triciribine with potential antineoplastic activity. Triciribine inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9.NCI
code
  • C1262
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