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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cordycepin
rdfs:subClassOf
Semantic_Type
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Cordycepin
NSC_Code
  • 401022
  • 627047
  • 63984
UMLS_CUI
  • C0056331
CAS_Registry
  • 73-03-0
Accepted_Therapeutic_Use_For
  • TdT-positive acute lymphocytic leukemia.
ALT_DEFINITION
  • An anticancer drug that belongs to a family of drugs called antitumor antibiotics.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42667
PDQ_Closed_Trial_Search_ID
  • 42667
Legacy_Concept_Name
  • Cordycepin
CHEBI_ID
  • CHEBI:29014
FULL_SYN
  • 9-CordyceposidoadenineSNNCI
  • CordycepineSYNCI
  • cordycepinPTNCI-GLOSSCDR0000045536
  • 3-dAdenosineSNNCI
  • 3'-dA-CE PhosphoramiditeSNNCI
  • CORABNCI
  • 3'-DeoxyadenosineSNNCI
  • CORDYCEPINSYDTPNSC0063984
  • KordicepinSYNCI
  • CordycepinPTNCI
DEFINITION
  • A purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity. Cordycepin is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. Triphosphate cordycepin can be incorporated into RNA, and inhibits transcription elongation and RNA synthesis due to the absence of a hydroxyl moiety at the 3' position. Because it can be converted to an inactive metabolite by adenosine deaminase, this agent must be administered with an adenosine deaminase inhibitor in order to be effective. Cordycepin has displayed cytotoxicity against some leukemic cell lines in vitro.NCI
code
  • C1057
is someValuesFrom of
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