About: Hypoxia-activated Prodrug PR610     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Hypoxia-activated Prodrug PR610
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Hypoxia-activated Prodrug PR610
NCI_META_CUI
  • CL435780
PDQ_Open_Trial_Search_ID
  • 732241
PDQ_Closed_Trial_Search_ID
  • 732241
FULL_SYN
  • PR610CNNCI
  • Hypoxia-activated Prodrug PR610PTNCI
DEFINITION
  • A proprietary, hypoxia-activated prodrug with potential antineoplastic activity. Upon administration, the hypoxia-activated prodrug PR610 is activated in the hypoxic cells within tumors into an irreversible pan-HER inhibitor via a mechanism of action not yet fully elucidated. As a result, this agent inhibits cellular proliferation and differentiation of tumor cells overexpressing HER kinases, which belong to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. Healthy, normal tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity.NCI
code
  • C101523
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