About: Basiliximab

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B437A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B437B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B437C-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	7.2 +/- 3.2 days (adults) (en)
http://linked.open...ugbank/indication	For prophylactic treatment of kidney transplant rejection (en)
sameAs	Basiliximab
Title	Basiliximab (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/drugbank/DB00074 http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/genbank/J00228 http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/national-drug-code-directory/0078-0393-61 http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/uniprotkb/P01857 http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/pharmgkb/PA164747126 http://linked.opendata.cz/resource/drugbank/drug/DB00074/identifier/wikipedia/Basiliximab
http://linked.open...mechanismOfAction	Basiliximab binds with high-affinity to the alpha-subunit (CD25) of the high-affinity IL-2 receptor. This inhibits IL-2 binding, which inhibits T-cell activation and prevents the body from mounting an immune response against the foreign kidney. (en)
http://linked.open...drugbank/packager	DAVA Pharmaceuticals
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2038279
http://linked.open.../drugbank/synonym	Ig gamma-1 chain C region (en) chimeric mouse-human antiCD25 (en)
http://linked.open...umeOfDistribution	* 7.8 ± 5.1 L [Pediatric] * 4.8 ± 2.1 L [Adult] (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/92-00-00
foaf:page	http://www.drugs.com/cdi/basiliximab.html http://www.rxlist.com/cgi/generic2/basiliximab.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4381-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4380-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Basiliximab
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	152923-56-3 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 41 +/- 19 mL/h [Adult patients undergoing first kidney transplantation] * 17 +/- 6 mL/h [pediatric patients undergoing renal transplantation] * 31 +/- 19 mL/h [adolescent patients undergoing renal transplantation] (en)
http://linked.open...gbank/containedIn	Efudex 50 mg/g Cream Simulect 20 mg vial
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B437E-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B437F-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B437D-363D-11E5-9242-09173F13E4C5

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