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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Resminostat
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Resminostat
NCI_META_CUI
  • CL412414
CAS_Registry
  • 864814-88-0
FDA_UNII_Code
  • 1578EUB98L
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 651465
PDQ_Closed_Trial_Search_ID
  • 651465
Chemical_Formula
  • C16H19N3O4S
FULL_SYN
  • ResminostatPTNCI
  • 4SC-201CNNCI
  • RESMINOSTATPTFDA1578EUB98L
DEFINITION
  • An orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity. Resminostat binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, inhibition of the transcription of tumor suppressor genes, inhibition of tumor cell division and the induction of tumor cell apoptosis. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins.NCI
code
  • C84856
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