About: Smoothened Antagonist BMS-833923

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About: Smoothened Antagonist BMS-833923 Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Smoothened Antagonist BMS-833923
rdfs:subClassOf	Signal Transduction Inhibitor
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Smoothened Antagonist BMS-833923
NCI_META_CUI	CL383601
PDQ_Open_Trial_Search_ID	596304
PDQ_Closed_Trial_Search_ID	596304
Legacy_Concept_Name	Smoothened_Antagonist_BMS-833923
FULL_SYN	XL139CNNCI BMS-833923CNNCI Smoothened Antagonist BMS-833923PTNCI Smoothened Antagonist BMS-833923SYNCI
DEFINITION	An orally bioavailable small molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO inhibitor BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.NCI
code	C77861

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