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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pracinostat
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pracinostat
NCI_META_CUI
  • CL376134
CAS_Registry
  • 929016-96-6
FDA_UNII_Code
  • GPO2JN4UON
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of several types of cancer. SB939 blocks the action of an enzyme called histone deacetylase (HDAC) and may stop tumor cells from dividing. It is a type of HDAC inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 559644
PDQ_Closed_Trial_Search_ID
  • 559644
Chemical_Formula
  • C20H30N4O2
Legacy_Concept_Name
  • HDAC_Inhibitor_SB939
FULL_SYN
  • PracinostatPTNCI
  • SB939PTNCI-GLOSSCDR0000561416
  • 2-propenamide, 3-(2-butyl-1-(2-(diethylamino)ethyl)-1h-benzimidazol-5-yl)-N-hydroxy-, (2E)-SNNCI
  • SB939CNNCI
  • kaempferol 3-o-beta-d-(6-E-P-coumaroylglucoside)SNNCI
  • HDAC Inhibitor SB939SYNCI
  • PRACINOSTATPTFDAGPO2JN4UON
DEFINITION
  • An orally available, small-molecule histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Pracinostat inhibits HDACs, which may result in the accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; the tumor suppressor protein-mediated inhibition of tumor cell division; and, finally, the induction of tumor cell apoptosis. This agent may possess improved metabolic, pharmacokinetic and pharmacological properties compared to other HDAC inhibitors.NCI
code
  • C71708
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