About: Barbiturate

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Barbiturate
rdfs:subClassOf	Sedative and Hypnotic
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Barbiturate
UMLS_CUI	C0004745
ALT_DEFINITION	A drug used to treat insomnia, seizures, and convulsions, and to relieve anxiety and tension before surgery. It belongs to the family of drugs called central nervous system (CNS) depressants.NCI-GLOSS
Legacy_Concept_Name	Barbiturate
CHEBI_ID	CHEBI:22693
FULL_SYN	BarbituratePTNCI barbituratePTNCI-GLOSSCDR0000044107
DEFINITION	A class of drugs characterized as central nervous system (CNS) depressants. Barbiturate compounds bind to the gamma amino butyric acid (GABA)-A receptor, thereby increasing the influx of chloride ions into the neuron and subsequently causing hyperpolarization, which produces a decrease in neuronal transmission. Other barbiturate effects in the CNS may include modulation of sodium and calcium channels as well as inhibition of glutamate-mediated excitation. Although the effects of barbiturates are seen throughout the CNS, the predominant effect occurs in the midbrain region, the part of the brain associated with arousal. CNS depressive effects associated with this drug class include mild sedation, hypnosis, anesthesia, and coma as well as a decrease in seizure activity.NCI
code	C67084
sameAs	Barbiturates
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0002177
is rdfs:subClassOf of	PENTOBARBITAL SODIUM PRIMIDONE SECOBARBITAL METHARBITAL METHOHEXITAL METHOHEXITAL SODIUM Nealbarbital SECOBARBITAL SODIUM TALBUTAL THIOPENTAL SODIUM MEPHOBARBITAL Probarbital Sodium Vinbarbital Thialbarbital Vinbarbital Sodium Methitural Thialbarbital Sodium THIOBUTABARBITAL Phenobarbital Calcium Phetharbital BUTALBITAL BUTABARBITAL PENTOBARBITAL BUTABARBITAL SODIUM THIAMYLAL THIAMYLAL SODIUM Hexobarbital Sodium PHENOBARBITAL Brallobarbital Tetrabarbital Allobarbital AMOBARBITAL AMOBARBITAL SODIUM APROBARBITAL BARBITAL Heptabarbital PHENOBARBITAL SODIUM BARBITAL NA MISCELLANEOUS Benzobarbital Eterobarb HEXOBARBITAL Cyclopentenylallylbarbituric Acid Butethal THIOBUTABARBITAL SODIUM
is sameAs of	Barbiturates

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