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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ocrelizumab
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ocrelizumab
UMLS_CUI
  • C1882138
CAS_Registry
  • 637334-45-3
FDA_UNII_Code
  • A10SJL62JY
Contributing_Source
  • FDA
Legacy_Concept_Name
  • Ocrelizumab
FULL_SYN
  • OcrelizumabPTNCI
  • OCRELIZUMABPTFDAA10SJL62JY
DEFINITION
  • A Fc-modified, humanized monoclonal antibody directed against the B-cell CD20 cell surface antigen, with immunosuppressive activity. Ocrelizumab binds to CD20 on the surfaces of B-cells, triggering complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) of B-cells overexpressing CD20. The CD20 antigen, a non-glycosylated cell surface phosphoprotein that acts as a calcium ion channel, is found on over 90% of B-cells, B-cell lymphomas, and other lymphoid tumor cells of B-cell origin; it plays an important role in B-cell functioning.NCI
code
  • C66250
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