About: Zalutumumab     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Zalutumumab
rdfs:subClassOf
Has_Target
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Zalutumumab
UMLS_CUI
  • C1831978
CAS_Registry
  • 667901-13-5
PDQ_Open_Trial_Search_ID
  • 518289
PDQ_Closed_Trial_Search_ID
  • 518289
Legacy_Concept_Name
  • Zalutumumab
FULL_SYN
  • ZalutumumabPTNCI
  • HuMax-EGFr, 2F8CNNCI
DEFINITION
  • A fully human IgG1 monoclonal antibody against epidermal growth factor receptor (EGFR) with potential antineoplastic activity. EGFR is a cell surface receptor tyrosine kinase, overexpressed on many cancer cells. Zalutumumab selectively binds to and blocks binding of EGF and transforming growth factor-alpha (TGF-a) to the EGFR receptor, thereby interfering with cellular signaling, leading to cell growth inhibition and apoptosis in tumor cells. In addition, zalutumumab also triggers cell lysis mediated through antibody dependent cellular cytotoxicity (ADCC) in EGFR-expressing cells.NCI
code
  • C64620
http://linked.open...y/mesh/hasConcept
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